- Clinical Biochemistry Lab Report: Validating a Method of M...
Clinical Biochemistry Lab Report: Validating a Method of Measuring Glucose Concentrations
Diabetes mellitus is a serious and growing health problem
worldwide. The disease is caused by a failure of the body to
adequately control the concentration of glucose in the blood, which
must be kept within narrow limits in order to allow the cells of
the body to function properly (Lawal, 2008). In type I diabetes,
autoimmune destruction of the insulin-producing pancreatic b-cells
leads to a lack of insulin in the blood, the key hormone which
regulates blood glucose levels. In contrast, late-onset type II
diabetes is characterised by high insulin levels but impaired
response of the tissues to this hormone.
Therefore, the first target for future work would be to repeat
the current experiment and demonstrate that this laboratory assay
can give extremely accurate readings when carried out effectively.
It may then be interesting to compare the performance of this assay
in the laboratory to the assay used by portable glucose monitors,
to assess to what extent the performance of these devices is
sub-optimal. In the long-term, it is hoped that further
technological advances may improve the accuracy of these monitors
to eliminate the possibility of dangerous readings (Montagnana et
Appropriately validating biochemical assays used for medical
purposes is critical. As diabetics need to keep their blood glucose
concentrations within narrow limits, it is crucial that the methods
used to measure blood glucose levels are properly tested and
validated to make sure they are sufficiently accurate to guide the
patient's insulin injections. This is also true for a whole range
of different biochemical assays used in a medical setting.