- Polyamines. Illustrate your essay with specific examples.
Polyamines. Illustrate your essay with specific examples.
The objective of this project was to synthesize a protected
spermidine derivative, which is a polyamine derivative. The
spermidine that was to be synthesised is a N8 protected
spermidine derivative. Other students have studied the synthesis of
N1 protected spermidine. A retrosynthetic analysis of
the required N8 protected spermidine derivative of was
carried out to devise a route to the product.
Unfortunately, this route proved unsatisfactory as due to
solubility problems and had to be abandoned. However, there are
other possible routes possible to synthesize the N8
protected spermidine derivative. The first route by Zhang et al
, provides stage 1 product
3-[(3-cyanopropyl)amino]propylamine. This route is a simple
nucleophilic addition reaction. The second route by Humora et al
, provides the stage 2 product called
Assign peak (1,2, 3 etc) to hydrogens on structure of stage
Assign peak (a,b, c etc) to carbons on structure of stage 2