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中文CAN ERYTHROPOIETIN AND MIMETICS BE USED AS NOVEL NEUROPROTECTIVE AGENTS?
Abstract Erythropoietin (EPO) is a glycopeptide hormone produced in the kidney in response to hypoxia. It is known for its role in red blood cell formation but has also, in recent years, been found in other locations like the central nervous system where its receptors are specifically expressed, suggesting an endogenous role in this location. […]
Analysis of analgesic tablet
The pain management therapy is based on the careful consideration of patients’ physiological status, severity of pain, and the disease type. Advances in understanding of biomolecular mechanisms of chronic pain continue to assist in the development of novel analgesics, which include non-opioid drugs (paracetamol, non-steroidal anti-inflammatory drugs – NSAIDs) and opioid drugs. According to WHO, […]
A Literature Review on Assay Development for Budesonide, Using MTT
Introduction Asthma is a condition affecting the respiratory system and is characterized by difficulty in breathing, wheezing, coughing and heaviness of chest. The symptoms are the results of narrowing down of the trachea, bronchi and other components of the respiratory system due to forceful contraction of smooth muscles on one hand and thickening of tissue […]
Clinical Governance
Introduction Following the Bristol Baby Scandal in 1995, which exposed the high mortality rate, observed in paediatric cardiac surgery at the Bristol Royal Infirmary, the term Clinical governance became widely used in the medical community. A need to improve and maintain the quality of care provided to general public was felt. This led to the […]
Future of NHS
Introduction NHS started its journey on July 5th, 1948 with three basic principles as guide to its future activities. These principles included meeting the needs of everyone, free services at the point of delivery and provision of services based on clinical needs instead of the individual’s ability to pay. The modernisation that took place in […]
Aspirin
History of the Drug Salicylic acid, the compound form from which aspirin was first derived, was found in the bark of the willow tree by Edmund Stone in England in 1763. Charles F. Gerhardt synthesized the first derivative of salicylic acid in 1853 (see Figures 1 and 2), but it wasn’t until 1899 that aspirin, […]
Critical Evaluation of approach to Health Needs Assessment: 'Screen & Manage Hazardous Drinkers within a Community Pharmacy Setting'
Defining Local need The level of alcohol consumption in the UK is rising, where nearly 6.4 million people drink up to 35-50 units per week and a further 1.8 million consume more than this per week (Scottish Executive, 1999-2000). The SIGN 74 Guideline (2003) has defined hazardous drinking as “regular consumption of over 5 units […]
The Immunoprecipitation Technique
Introduction Immunoprecipitation (IP) is a powerful method in molecular biology and biochemistry that involves the identification and isolation of particular proteins from a solution, tissue or lysate by employing the use of antibodies specific to the protein of interest. The process of IP has been employed by researchers to develop a number of experimental and […]
Monograph for Isoniazid (isonicotinyl hydrazine or INH)
Introduction Tuberculosis is an infection caused by M tuberculosis which affects millions of people worldwide. The first reasonable cure for tuberculosis was considered at the discovery of isoniazid 1952 by Roche who trademarked it as Rimifon®. Currently INH is used as the first-line antituberculous medication for prophylaxix and treatment of tubercule infection. However isoniazid is […]
Executive Summary
Background Constipation is a problem which has been observed to commonly effect the elderly population, especially those above the age of 60 years, with prevalence rates being about 31%.1 There are currently no national guidelines for the treatment of constipation. Both the NPC and CKS guidelines suggest a stepped approach towards management where first line […]
